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The term antelope refers to numerous extant or recently extinct species of the ruminant artiodactyl family Bovidae that are indigenous to most of Africa, India, the Middle East, Central Asia, and a small area of Eastern Europe. Antelopes do not form a monophyletic group, as some antelopes are more closely related to other bovid groups, such as bovines, goats, and sheep, than to other antelopes.

A stricter grouping, known as the true antelopes, includes only the genera Gazella, Nanger, Eudorcas, and Antilope. One North American mammal, the pronghorn or "pronghorn antelope", is colloquially referred to as the "American antelope", despite the fact that it belongs to a completely different family (Antilocapridae) than the true Old-World antelopes; pronghorn are the sole extant member of an extinct prehistoric lineage that once included many unique species.

Although antelope are sometimes referred to, and easily misidentified as, "deer" (cervids), true deer are only distant relatives of antelopes. While antelope are found in abundance in Africa, only one deer species is found on the continent—the Barbary red deer of Northern Africa. By comparison, numerous deer species are usually found in regions of the world with fewer or no antelope species present, such as throughout Southeast Asia, Europe and all of the Americas. This is likely due to competition over shared resources, as deer and antelope fill a virtually identical ecological niche in their respective habitats. Countries like India, however, have large populations of endemic deer and antelope, with the different species generally keeping to their own "niches" with minimal overlap.

Unlike deer, in which the males sport elaborate head antlers that are shed and regrown annually, antelope horns are bone and grow steadily, never falling off. If a horn is broken, it will either remain broken or take years to partially regenerate, depending on the species of the antelope.